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★★★★☆High Energy— $8.45 (Save 55%!)

High Energy Supplement: * Increases energy and alertness. * Strengthens immune function. * Relieves stress and improves oxygen levels. * Acts as an antidepressant. * Increases sexual interest. * Mobilizes blood sugar from the liver. * Promotes a healthy nervous system. PRODUCT ADVANTAGES: 1. Formulated with 6 essential stimulants to keep your body and mind alert. 2. Provides an individual with the extra energy to keep on going after numerous hours during a busy work day. 3. Tablets do not have any of the other side effects of NoDoz type products. 4. Used by millions of people every day to help them remain alert and focused. Siberian Ginseng: * Increases energy and alertness * Strengthens immune function * Relieves stress * Improves oxygen levels Kola Nut Extract: * Small amount of caffeine, stimulant Lysine: * Helps improve oxygen levels * Useful treatment for angina Phenylalanine: * Improves memory and mental alertness * Acts as an antidepressant * Increases sexual interest Glycine: * Serves as a stimulant to the brain * Produces glycogen which mobilizes blood sugar from the liver Cyanocobalamin: * Helps form and regenerate red blood cells which carry oxygen to the tissue, giving you more energy * Improves circulation, memory and balance * Promotes a healthy nervous system PRODUCT DOSAGE: Take 1 to 2 tablets 3 times a day to maintain mental focus and alertness. All 6 ingredients contained within contain 100% Pure Pharmaceutical Grade Ingredients. High Energy is a safe and highly effective energy booster supplement for individuals of all ages, sexes, and backgrounds. Each HIGH ENERGY tablet contains the following ingredients: Ingredients...................................................... Amount Siberian Ginseng.................................................20 mg Kola Nut Extract.................................................300 mg Lysine................................................................100 mg Phenylalanine...................................................100 mg Glycine..............................................................100 mg Cyanocobalamin...............................................200 mcg

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Sleep Essentials— $10.99 (Save 31%!)

Sleep Essentials

Caps Size: OO, Pill Size Guide Size: 120 Caps Natural support with the help of melatonin and a combination of relaxation herbs Featuring valerian root, chamomile flower powder, hops flower powder, scullcap herb powder, L-taurine and GABA Swanson Sleep Essentials is the perfect blend of potent herbs and nutrients for those nights where sleep isn't coming by itself. The combination of melatonin and calming herbs, including passion flower, valerian, chamomile, skullcap and hops, will work together to bring you restful and relaxing sleep. Supplement Facts Serving Size 1 Capsule Amount Per Serving % Daily Value Calcium (from calcium carbonate) 40 mg 4% Magnesium (from magnesium oxide) 30 mg 8% Valerian Root (Valeriana officinalis) 100 mg * Chamomile Flower (Matricaria chamomilla) 75 mg * Hops Flower (Humulus lupulus) 75 mg * Scullcap Herb (Scutellaria sp.) (aerial parts) 75 mg * L-Taurine 50 mg * Passionflower (flower and leaf) 50 mg * GABA (gamma-aminobutyric acid) 25 mg * Melatonin 3 mg * *Daily Value not established. Other ingredients: Rice flour, gelatin, magnesium stearate. Suggested Use: As a dietary supplement, take one capsule before bed with 8 ounces of water. WARNING: As melatonin may produce drowsiness, do not drive an automobile or operate heavy equipment after taking. Do not take this product if you are pregnant or nursing, have an autoimmune condition or a depressive disorder, or are under 16 years of age. Melatonin Listeni/ËŒmÉ›lÉ™ËˆtoÊŠnÉªn/, also known chemically as N-acetyl-5-methoxytryptamine,[1] is a naturally occurring compound found in animals, plants, and microbes.[2][3] In animals, circulating levels of the hormone melatonin vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions.[4] Many biological effects of melatonin are produced through activation of melatonin receptors,[5] while others are due to its role as a pervasive and powerful antioxidant,[6] with a particular role in the protection of nuclear and mitochondrial DNA.[7] Melatonin has been identified in many plants including feverfew (Tanacetum parthenium), St John's wort (Hypericum perforatum).,[3] rice, corn, tomato and edible fruits.[9] The physiological roles of melatonin in plants involve regulation of their response to photoperiod, defense against harsh environments, and the function of an antioxidant. The latter may be the original function of melatonin in organisms with the others being added during evolution.[10] Melatonin also regulates plant growth by its ability to slow root formation, while promoting above ground growth.[11] Melatonin has been reported in foodstuffs including cherries to about 0.17-13.46 ng/g,[12] bananas and grapes, rice and cereals, herbs, olive oil, wine[13] and beer. When humans consume foods rich in melatonin such as banana, pineapple and orange the blood levels of melatonin significantly increased.[15] Humans Circadian rhythm In humans, melatonin is produced by the pineal gland, a small endocrine gland[26] located in the center of the brain but outside the bloodâ€“brain barrier. The melatonin signal forms part of the system that regulates the sleep-wake cycle by chemically causing drowsiness and lowering the body temperature, but it is the central nervous system (specifically the suprachiasmatic nuclei, or SCN)[26] that controls the daily cycle in most components of the paracrine and endocrine systems[27][28] rather than the melatonin signal (as was once postulated). Infants' melatonin levels become regular in about the third month after birth, with the highest levels measured between midnight and 08:00 (8 AM).[29] In humans, 90% of melatonin is cleared in a single passage through the liver, a small amount is excreted in urine,[30] and a small amount is found in saliva. Human melatonin production decreases as a person ages.[31] It is believed that as children become teenagers, the nightly schedule of melatonin release is delayed, leading to later sleeping and waking times.[32] Light dependence Production of melatonin by the pineal gland is inhibited by light to the retina and permitted by darkness. Its onset each evening is called the dim-light melatonin onset (DLMO). It is principally blue light, around 460 to 480 nm, that suppresses melatonin,[33] proportional to the light intensity and length of exposure. Until recent history, humans in temperate climates were exposed to few hours of (blue) daylight in the winter; their fires gave predominantly yellow light. The incandescent light bulb widely used in the twentieth century produced relatively little blue light.[34] Wearing glasses that block blue light in the hours before bedtime may decrease melatonin loss. Kayumov et al. showed that light containing only wavelengths greater than 530 nm does not suppress melatonin in bright-light conditions.[35] Use of blue-blocking goggles the last hours before bedtime has also been advised for people who need to adjust to an earlier bedtime, as melatonin promotes sleepiness.[36] When used several hours before sleep according to the phase response curve for melatonin in humans, small amounts (0.3 mg[37]) of melatonin shift the circadian clock earlier, thus promoting earlier sleep onset and morning awakening.[38] Antioxidant Besides its function as synchronizer of the biological clock, melatonin was found to be a powerful free radical scavenger and wide spectrum antioxidant in 1993.[39] In many less complex life forms, this is its only known function.[40] Melatonin is an antioxidant that can easily cross cell membranes[41] and the bloodâ€“brain barrier.[6][42] This antioxidant is a direct scavenger of radical oxygen and nitrogen species including: OH, O2âˆ’, and NO.[11][43] Melatonin works with other antioxidants to improve the overall effectiveness from each antioxidant.[11] Unlike other antioxidants, melatonin does not undergo redox cycling, the ability of a molecule to undergo reduction and oxidation repeatedly. Redox cycling may allow other antioxidants (such as vitamin C) to act as pro-oxidants, counterintuitively promoting free radical formation. Melatonin, on the other hand, once oxidized, cannot be reduced to its former state because it forms several stable end-products upon reacting with free radicals. Therefore, it has been referred to as a terminal (or suicidal) antioxidant.[41]:p.189[44] Recent research indicates that the first metabolite of melatonin in the melatonin antioxidant pathway may be N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (or AFMK) rather than the common, excreted 6-hydroxymelatonin sulfate. AFMK alone is detectable in unicellular organisms and metazoans. A single AFMK molecule can neutralize up to 10 ROS/RNS (reactive oxygen species/reactive nitrogen species) since many of the products of the reaction/derivatives (including melatonin) are themselves antioxidants. This capacity to absorb free radicals extends at least to the quaternary metabolites of melatonin, a process referred to as "the free radical scavenging cascade." This is not true of other, conventional antioxidants.[40] In animal models, melatonin has been demonstrated to prevent the damage to DNA by some carcinogens, stopping the mechanism by which they cause cancer.[45] It also has been found to be effective in protecting against brain injury caused by ROS release in experimental hypoxic brain damage in newborn rats.[46] Melatonin's antioxidant activity may reduce damage caused by some types of Parkinson's disease, play a role in preventing cardiac arrhythmia and possibly increase longevity; it has been shown to increase the average life span of mice by 20% in some studies.[47][48][49] Immune system While it is known that melatonin interacts with the immune system,[50][51] the details of those interactions are unclear. There have been few trials designed to judge the effectiveness of melatonin in disease treatment. Most existing data are based on small, incomplete clinical trials. Any positive immunological effect is thought to be the result of melatonin acting on high affinity receptors (MT1 and MT2) expressed in immunocompetent cells. In preclinical studies, melatonin may enhance cytokine production,[52] and by doing this counteract acquired immunodeficiences. Some studies also suggest that melatonin might be useful fighting infectious disease[21] including viral, such as HIV, and bacterial infections, and potentially in the treatment of cancer.[53] Endogenous melatonin in human lymphocytes has been related to interleukin-2 (IL-2) production and to the expression of IL-2 receptor.[54] This suggests that melatonin is involved in the clonal expansion of antigen-stimulated human T lymphocytes. In rheumatoid arthritis patients, melatonin production has been found increased when compared to age-matched healthy controls.[55]

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Wednesday, July 13, 2016

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